Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS
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چکیده
منابع مشابه
Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS
Methylation is an essential and ubiquitous reaction that plays an important role in a wide range of biological processes. Most biological methylations use S-adenosylmethionine (SAM) as the methyl donor and proceed via an S(N)2 displacement mechanism. However, researchers have discovered an increasing number of methylations that involve radical chemistry. The enzymes known to catalyze these reac...
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The radical S-adenosylmethionine (S-AdoMet) superfamily contains thousands of proteins that catalyze highly diverse conversions, most of which are poorly understood, owing to a lack of information regarding chemical products and radical-dependent transformations. We here report that NosL, involved in forming the indole side ring of the thiopeptide nosiheptide (NOS), is a radical S-AdoMet 3-meth...
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ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2011
ISSN: 0001-4842,1520-4898
DOI: 10.1021/ar200202c